Of course. Every setting has a limit.
The -n parameter determines how many database connections you can have concurrently. It includes all types of connections (4GL clients, SQL clients, utilities, helper processes, etc.), except for servers and brokers.
The question shouldn't be about the architectural limits, which you aren't likely to require. The question is how many concurrent connections do you need, from a business perspective? And, related, how many are you licensed for?